LeHavreV1, Main, Exploration, bibRecord, 000642

A time series study of drug sales and turbidity of tap water in Le Havre, France.

Identifieur interne : 000642 ( Main/Exploration ); précédent : 000641; suivant : 000643

A time series study of drug sales and turbidity of tap water in Le Havre, France.

Auteurs : Pascal Beaudeau [France] ; Alain Le Tertre ; Abdelkrim Zeghnoun ; Antonella Zanobetti ; Joel Schwartz

Source :

Journal of water and health [ 1477-8920 ] ; 2012.

RBID : pubmed:22717747

Descripteurs français

Wicri :
- geographic : France.

English descriptors

KwdEn :
- Drug Prescriptions (economics), Economics, Pharmaceutical (trends), Environmental Monitoring, Epidemiological Monitoring, France (epidemiology), Gastroenteritis (drug therapy), Gastroenteritis (epidemiology), Humans, Models, Biological, Models, Statistical, Time Factors, Water (chemistry), Water Supply (standards).
MESH :
- chemical , chemistry : Water.
- geographic , epidemiology : France.
- drug therapy : Gastroenteritis.
- economics : Drug Prescriptions.
- epidemiology : Gastroenteritis.
- standards : Water Supply.
- trends : Economics, Pharmaceutical.
- Environmental Monitoring, Epidemiological Monitoring, Humans, Models, Biological, Models, Statistical, Time Factors.

Abstract

The 80,000 inhabitants of the lower part of Le Havre obtain their water supply from two karstic springs, Radicatel and Saint-Laurent. Until 2000, the Radicatel water was settled when turbidity exceeded 3 NTU, then filtered and chlorinated, whereas the Saint-Laurent water was simply chlorinated. Our study aimed to characterize the link between water turbidity and the incidence of acute gastroenteritis (AGE). Records on drug sales used for the treatment of AGE were collected from January 1994 to June 1996 (period 1) and from March 1997 to July 2000 (period 2). Daily counts of drug sales were modeled using a Poisson Regression. We used data set 2 as a discovery set, identifying relevant (i.e. both significant and plausible) exposure covariates and lags. We then tested this model on period 1 as a replication dataset. In period 2, the daily drug sales correlated with finished water turbidity at both resources. Settling substantially modified the risk related to turbidity of both raw and finished waters at Radicatel. Correlations were reproducible in period 1 for water from the Radicatel spring. Timeliness of treatment adaptation to turbidity conditions appears to be crucial for reducing the infectious risk due to karstic waters.

DOI: 10.2166/wh.2012.157
PubMed: 22717747

Affiliations:

France

Le document en format XML

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<front><div type="abstract" xml:lang="en">The 80,000 inhabitants of the lower part of Le Havre obtain their water supply from two karstic springs, Radicatel and Saint-Laurent. Until 2000, the Radicatel water was settled when turbidity exceeded 3 NTU, then filtered and chlorinated, whereas the Saint-Laurent water was simply chlorinated. Our study aimed to characterize the link between water turbidity and the incidence of acute gastroenteritis (AGE). Records on drug sales used for the treatment of AGE were collected from January 1994 to June 1996 (period 1) and from March 1997 to July 2000 (period 2). Daily counts of drug sales were modeled using a Poisson Regression. We used data set 2 as a discovery set, identifying relevant (i.e. both significant and plausible) exposure covariates and lags. We then tested this model on period 1 as a replication dataset. In period 2, the daily drug sales correlated with finished water turbidity at both resources. Settling substantially modified the risk related to turbidity of both raw and finished waters at Radicatel. Correlations were reproducible in period 1 for water from the Radicatel spring. Timeliness of treatment adaptation to turbidity conditions appears to be crucial for reducing the infectious risk due to karstic waters.</div>
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A time series study of drug sales and turbidity of tap water in Le Havre, France.

A time series study of drug sales and turbidity of tap water in Le Havre, France.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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